| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 1 | First XI | 1980-10-04 | Murrumbeena | lost to | Spotswood |
| 9/94 P Hay 28 | | 97 J Graham 3/22 P Way 5/22 |
| 2 | Second XI | 1980-10-11 | Murrumbeena | lost to | Royal Park |
| 9/104 A Roach 47 | | 6/105 S Goold 4/19 |
| 3 | Second XI | 1980-10-18 | Bentleigh | def | Murrumbeena |
| 8/254 J Crombie 4/88 S Goold 2/49
and 1/13 | | 145 G Burns 46 |
| 5 | Second XI | 1980-11-15 | Murrumbeena | lost to | Brunswick District |
| 134 R Coghill 33 M O'Neill 36* | | 179 G Burns 5/29 S Goold 3/46 J Crombie 2/55
and 1/32 |
| 6 | Second XI | 1980-11-29 | Hampton | def | Murrumbeena |
| 9/153 G Keetley 3/29 J Crombie 3/31 | | 111 S Hay 36
and 14 |
| 7 | First XI | 1980-12-20 | East Malvern | def | Murrumbeena |
| 3/162 D Hardham 2/18 | | 68 |
| 8 | First XI | 1981-01-17 | Murrumbeena | lost to | South Caulfield |
| 83 | | 5/124 P Way 3/38 |
| 9 | First XI | 1981-01-24 | Altona North | def | Murrumbeena |
| 254 A Graham 2/56 P Way 4/28 | | 147 D Hardham 31 |
| 10 | First XI | 1981-01-26 | Murrumbeena |  | Highett |
| 139 G Hickey 33 P Way 25 | | 86 J Graham 2/14 R Parker 3/38 S Goold 2/13 |
| 11 | First XI | 1981-02-14 | Moorabbin Park | def | Murrumbeena |
| 8/177 J Graham 2/36 D Hardham 2/34 P Way 2/36 S Goold 2/28 | | 9/103 P Hay 38 |
| 12 | First XI | 1981-02-21 | Murrumbeena | lost to | Altona North |
| 161 D Hardham 27 A Graham 55
and 107 | | 187 D Hardham 3/20 P Way 6/42 |
